Aminosugar-based immunomodulator lipid A: synthetic approaches
نویسندگان
چکیده
منابع مشابه
Aminosugar-based immunomodulator lipid A: synthetic approaches
The immediate immune response to infection by Gram-negative bacteria depends on the structure of a lipopolysaccharide (LPS, also known as endotoxin), a complex glycolipid constituting the outer leaflet of the bacterial outer membrane. Recognition of picomolar quantities of pathogenic LPS by the germ-line encoded Toll-like Receptor 4 (TLR4) complex triggers the intracellular pro-inflammatory sig...
متن کاملSynthetic approaches toward sesterterpenoids.
Sesterterpenoids account for many bioactive natural products, often with unusual and complex structural features, which makes them attractive targets for synthetic chemists. This review surveys efforts undertaken toward the synthesis of sesterterpenoids, focusing on completed total syntheses and covering ca. 50 natural products in total.
متن کاملDendrimers: a Review on Synthetic Approaches
Article history: Received on: 16/12/2014 Revised on: 19/01/2015 Accepted on: 07/02/2015 Available online: 28/03/2015 This review article is focused on different synthetic strategies used in dendrimer synthesis at commercial and laboratory scale. These synthetic strategies includes their own advantages and disadvantages. This review will cover divergent (from core to surface) and convergent (fro...
متن کاملGraphene-based hybrid materials: synthetic approaches and properties
Carbon has a unique chemistry reflected in its wide presence in the inorganic and organic world – benzene, diamond, graphite, fullerene, carbon nanotubes and now graphene – carbon seems to be at the centre of action in the playground of scientific research. In this review, synthesis and unique properties of graphene and graphene-based composites have been discussed with particular emphasis on t...
متن کاملVaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins
Vaccinia virus interferes with early events of the activation pathway of the transcriptional factor NF-kB by binding to numerous host TIR-domain containing adaptor proteins. We have previously determined the X-ray structure of the A46 C-terminal domain; however, the structure and function of the A46 N-terminal domain and its relationship to the C-terminal domain have remained unclear. Here, we ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2018
ISSN: 1860-5397
DOI: 10.3762/bjoc.14.3